Mayo Clinic's approach

Mayo Clinic's world-renowned surgeons are trained in transsphenoidal surgery and other treatments for pituitary tumors. Mayo Clinic endocrinologists also are leaders in treating hormone-producing pituitary tumors.

At Mayo Clinic, endocrinologists with expertise in pituitary disease coordinate a team to comprehensively evaluate pituitary tumors, and develop a treatment plan based on your needs.

Your care team may include specialists from:

Collaboration

Mayo Clinic healthcare professionals include a multidisciplinary team of experts in many specialties to provide comprehensive care for patients who need transsphenoidal surgery. They work with experts in brain and nervous system imaging (radiologists) and with experts who specialize in the ear, nose, throat and head and neck (otolaryngologists). They also work with radiation oncology and pain medicine specialists.

People with pituitary tumors who receive care in the Mayo Clinic Brain Tumor Program are treated by internationally respected doctors who specialize in this type of brain tumor. They use the latest technology and techniques to develop a treatment plan tailored to each situation.

State-of-the-art technology

Mayo Clinic offers the latest technology to help treat pituitary tumors and perform transsphenoidal surgery.

Mayo Clinic's neuroradiologists are experienced in performing a test in which a sample is taken from the veins where the pituitary gland drains hormones into the bloodstream. Called inferior petrosal sinus sampling, this test is used to help find and identify pituitary tumors.

In people with Cushing syndrome, some pituitary adenomas cause excess production of adrenocorticotropic hormone, also known as ACTH. These tumors may be too small for detection with traditional MRI scans. Mayo Clinic uses a high-field, 3-tesla MRI scanner to help diagnose and provide clearer images of some pituitary adenomas.

Mayo Clinic was one of the first hospitals to extensively research an endoscopic through-the-nose, also called transnasal, surgical technique to remove tumors. This method is now standard practice. The endoscopic transnasal technique is highly successful, lowers discomfort and usually requires only an overnight stay in the hospital. When performed by doctors experienced with this method, it has proved to be highly successful and usually reduces the length of the hospital stay and the level of discomfort.

Expertise

The state-of-the-art Mayo Clinic Endocrine Testing Center accurately and safely performs complex hormonal stimulation and suppression tests. These tests are used to identify the types of pituitary tumors and how well the pituitary gland is working. These tests are essential in planning transsphenoidal surgery and creating a comprehensive treatment plan.

Expertise and rankings

Mayo Clinic in Rochester, Minnesota, is ranked No. 1 for endocrinology, and ranks among the top hospitals for neurology and neurosurgery, cancer, and ear, nose and throat surgery in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida are ranked among the top hospitals for neurology and neurosurgery, for cancer, for ear, nose and throat surgery, and for endocrinology by U.S. News & World Report.

Experience

Mayo Clinic's highly specialized surgical teams perform many transsphenoidal surgeries each year. When integrated with ongoing research and education, this results in broad expertise and the latest advancements in transsphenoidal surgery.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

May 17, 2025
  1. Transsphenoidal surgery. NCI Dictionary of Cancer Terms. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/transsphenoidal-surgery. Accessed April 17, 2025.
  2. Kuo JS, et al. Congress of Neurological Surgeons systematic review and evidence-based guideline on surgical techniques and technologies for the management of patients with nonfunctioning pituitary adenomas. Neurosurgery. 2016; doi:10.1227/NEU.0000000000001390.
  3. Quinones-Hinojosa A, et al., eds. Endoscopic endonasal pituitary and skull base surgery. In: Schmidek & Sweet: Operative Neurosurgical Techniques. 7th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed April 17, 2025.
  4. Swearingen B. Transsphenoidal surgery for pituitary adenomas and other sellar masses. https://www.uptodate.com/contents/search. Accessed April 17, 2025.
  5. Winn HR, ed. Avoidance of complications in neurosurgery. In: Youmans and Winn Neurological Surgery. 8th ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed April 17, 2025.
  6. Gropper MA, et al., eds. Anesthesia for neurologic surgery and neurointerventions. Miller's Anesthesia. 10th ed. 2025; Elsevier. https://www.clinicalkey.com. Accessed April 17, 2025.
  7. Guinto G, et al. Current and future perspectives of microscopic and endoscopic transsphenoidal surgery for pituitary adenomas: A narrative review. Archives of Medical Research. 2023; doi:10.1016/j.arcmed.2023.102872.
  8. Fang CH, et al. Overview of pituitary surgery. Otolaryngologic Clinics of North America. 2022; doi:10.1016/j.otc.2022.01.001.
  9. Rennert RC, et al. Microscopic transsphenoidal surgery in the era of endoscopy: Are there any advantages? Otolaryngologic Clinics of North America. 2022; doi:10.1016/j.otc.2021.12.010.
  10. Chavez-Herrera VR, et al. Endonasal endoscopic surgery for pituitary adenomas. Clinical Neurology and Neurosurgery. 2024; doi:10.1016/j.clineuro.2024.108172.
  11. Shafiq I, et al. Advancement in perioperative management of pituitary adenomas — Current concepts and best practices. Journal of Neuroendocrinology. 2024; doi:10.1111/jne.13427.
  12. Perez-Vega C, et al. Fluid restriction after transsphenoidal surgery for the prevention of delayed hyponatremia: A systematic review and meta-analysis. Endocrine Practice. 2021; doi:10.1016/j.eprac.2021.07.003.
  13. Zhou Z, et al. Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: A meta-analysis and systematic review. BMC Neurology. 2021; doi:10.1186/s12883-021-02440-0.
  14. Pituitary tumors treatment — For health professionals. National Cancer Institute. http://www.cancer.gov/types/pituitary/hp/pituitary-treatment-pdq#section/all. Accessed May 2, 2025.
  15. Surgery for pituitary tumors. American Cancer Society. https://www.cancer.org/cancer/types/pituitary-tumors/treating/surgery.html. Accessed April 25, 2025.
  16. Swearingen, B. Transsphenoidal surgery for pituitary adenomas and other sellar masses. https://www.uptodate.com/contents/search. Accessed April 25, 2025.
  17. Shih HA. Radiation therapy of pituitary tumors. https://www.uptodate.com/contents/search. Accessed April 25, 2025.
  18. Health Education & Content Services. Endoscopic transsphenoidal pituitary surgery. Mayo Clinic; 2023.
  19. Health Education & Content Services. Preparing for your surgery or procedure. Mayo Clinic; 2023.