Mayo Clinic's approach

Your Mayo Clinic care team

Mayo Clinic Comprehensive Cancer Center takes a patient-centered approach to cancer care. Teams work across specialties including colon and rectal surgery, medical oncology, and gastroenterology and hepatology to provide a comprehensive care plan that keeps you and your needs at the center. Mayo Clinic's seamless care experience lets you focus on healing while your care team addresses the many challenges that arise with a cancer diagnosis.

Expertise

At this time, a number of select healthcare facilities across the world have HIPEC available. These centers provide a great deal of specialization and coordination among medical specialties, as well a significant amount of operational support and resources. In the U.S., Mayo Clinic is among the handful of medical centers that provides HIPEC as an option to its patients.

Faster recovery

To promote faster healing and a smoother recovery, Mayo Clinic uses the Enhanced Recovery After Surgery (ERAS) program. ERAS is designed to help you get better faster by focusing on nutrition, pain management and physical activity before and after your procedure.

Expertise and rankings

Nationally recognized expertise

Outside organizations recognize Mayo Clinic cancer specialists through accreditations, grants and rankings:

  • Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute comprehensive cancer center and is the only such center with three unique locations. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.
  • Mayo Clinic is among the highest-ranked cancer centers in the nation according to U.S. News & World Report.
  • Mayo Clinic ranks No. 1 in the nation for gastroenterology and GI surgery according to U.S. News & World Report.
  • Mayo Clinic is accredited by the American College of Surgeons' Commission on Cancer.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Rochester, Minnesota, is ranked as the top hospital in Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, is ranked as the top hospital in Arizona, and Mayo Clinic in Jacksonville, Florida, is ranked the top hospital in Florida.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

May 23, 2025
  1. Hyperthermic intraperitoneal chemotherapy. NCI Dictionary of Cancer Terms. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hyperthermic-intraperitoneal-chemotherapy. Accessed April 3, 2025.
  2. Van der Speeten K, et al. The 2022 PSOGI international consensus on HIPEC regimens for peritoneal malignancies: HIPEC technologies. Annals of Surgical Oncology. 2024; doi:10.1245/s10434-024-15513-4.
  3. Bhatt A, et al. The 2022 PSOGI international consensus on HIPEC regimens for peritoneal malignancies: Epithelial ovarian cancer. Annals of Surgical Oncology. 2023; doi:10.1245/s10434-023-13932-3.
  4. Kusamura S, et al. The 2022 PSOGI international consensus on HIPEC regimens for peritoneal malignancies: Pseudomyxoma peritonei. Annals of Surgical Oncology. 2024; doi:10.1245/s10434-024-15646-6.
  5. Hübner M, et al. 2022 Peritoneal Surface Oncology Group international consensus on HIPEC regimens for peritoneal malignancies: Colorectal cancer. Annals of Surgical Oncology. 2024; doi:10.1245/s10434-023-14368-5.
  6. Hübner M, et al. Guidelines for perioperative care in cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC): Enhanced recovery after surgery (ERAS) society recommendations — Part I: Preoperative and intraoperative management. European Journal of Surgical Oncology. 2020; doi:10.1016/j.ejso.2020.07.041.
  7. Hübner M, et al. Guidelines for perioperative care in cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC): Enhanced recovery after surgery (ERAS) society recommendations — Part II: Postoperative management and special considerations. European Journal of Surgical Oncology. 2020; doi:10.1016/j.ejso.2020.08.006.
  8. Gearing PF, et al. Perioperative nutritional assessment and interventions in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): A systematic review. European Journal of Surgical Oncology. 2023; doi:10.1016/j.ejso.2023.02.015.
  9. Chen D, et al. Risk factors for postoperative complications in patients undergoing cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: A meta-analysis and systematic review. International Journal of Colorectal Disease. 2024; doi:10.1007/s00384-024-04741-5.
  10. Lewis AL, et al. Anesthesia for cytoreductive surgery with heated intraperitoneal chemotherapy. https://www.uptodate.com/contents/search. Accessed April 3, 2025.
  11. Ramirez PT, et al., eds. Hyperthermic intraperitoneal chemotherapy (HIPEC). In: Principles of Gynecologic Oncology Surgery. 2nd ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed April 3, 2025.
  12. Hagberg C. Anesthesia and surgery for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). In: Perioperative Care of the Cancer Patient. Elsevier; 2023. https://www.clinicalkey.com. Accessed April 3, 2025.
  13. Karimi M, et al. Challenges following CRS and HIPEC surgery in cancer patients with peritoneal metastasis: A comprehensive review of clinical outcomes. Frontiers in Surgery. 2024; doi:10.3389/fsurg.2024.1498529.
  14. Tsolakidis D, et al. Evaluating the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on interval and secondary debulking in ovarian cancer: A systematic review. Cancers. 2025; doi:10.3390/cancers17050904.
  15. Yang G, et al. Postoperative follow-up compliance and survival analysis in pseudomyxoma peritonei patients treated with CRS and HIPEC: A six-year retrospective study. World Journal of Surgical Oncology. 2024; doi:10.1186/s12957-024-03598-w.
  16. Morgan RB, et al. Quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A narrative review. Digestive Medicine Research. 2020; doi:10.21037/dmr-20-153.

Hyperthermic intraperitoneal chemotherapy (HIPEC)