Mouth sores caused by cancer treatment: How to cope

Understand how to manage cancer treatment side effects, including mouth sores, so you can feel more in control as you go through cancer treatment.

By Mayo Clinic Staff

If you're about to start cancer treatment, know that certain treatments can cause mouth sores. The term that health care providers use for mouth sores is oral mucositis.

Mouth sores can hurt and feel uncomfortable. They can range from minor problems to severe complications. They could make you stop your cancer treatment. These sores can make it hard to drink and could make you lose weight because you can't eat enough.

What are cancer-related mouth sores?

Cancer-related mouth sores form on the inside of your mouth or on your lips. The sores look like burns and can hurt. Mouth sores can make it hard to eat, talk, swallow and breathe.

Sores can happen anywhere on the soft tissues of your lips or your mouth. Sores can happen on the gums, the inside of your cheeks, tongue, and roof or floor of the mouth. Sores can also happen in the tube that carries the food you swallow to your stomach. This tube is called the esophagus.

Which cancer treatments cause mouth sores?

In general, cancer treatments that can cause mouth sores include:

  • Chemotherapy
  • Radiation therapy aimed at the head and neck
  • Bone marrow transplant, also known as a stem cell transplant
  • Targeted therapy
  • Immunotherapy

Whether your cancer treatment will cause mouth sores depends on which treatments you have and what doses you receive. Ask your health care provider whether your specific medicines or treatments might cause mouth sores.

What can I do to prevent mouth sores?

Although there's no sure way to prevent mouth sores, you can lower your risk. Talk to your health care provider about your risk of mouth sores and what you can do.

Your provider might recommend that you:

  • Get a dental checkup. Visit your dentist before you begin cancer treatment. Make sure to take care of any current issues with your mouth. These can include gum disease, cavities or teeth that need to be pulled. Any pain or infections in your mouth will get worse after you begin treatment. Continue regular dental checkups during treatment, especially if you have mouth sores.
  • Tell your provider if you have a history of mouth sores. If you've had mouth sores in the past, tell your provider. For example, tell your provider if you've had mouth sores caused by herpes simplex virus. Your provider might recommend medicine to prevent those types of mouth sores from happening during cancer treatment.
  • Take care of your teeth. Brush your teeth and rinse your mouth several times a day. Check the labels on mouthwashes and don't use alcohol-based products.

    Floss every day, especially after eating. Develop a routine for your mouth care now. That will make it easier to continue during your treatment.

  • Stop smoking. If you smoke, quit. Smoking during treatment will make it harder for your mouth to heal itself.
  • Eat a diet with lots of fruits and vegetables. Choose a diet that includes plenty of fruits and vegetables. You'll need the vitamins and nutrients they provide to help your body fight infections during treatment.

Your provider may recommend other ways to reduce your risk of mouth sores, such as:

  • Using ice or water to keep your mouth cold. During certain types of chemotherapy treatment, it might help to swish ice chips or cold water around in your mouth. The cold limits the amount of treatment that reaches your mouth. This can lower your risk of mouth sores.
  • Medicine. Medicines to lower the risk of mouth sores might be an option for people having certain cancer treatments. These medicines might help those having bone marrow transplants or certain targeted therapy treatments.

How are mouth sores treated?

Even if you try to prevent mouth sores, you may still get them. Treatment for mouth sores can help control the pain as you wait for the cells in your mouth to heal.

Tell your health care provider if your mouth feels sensitive or you notice any sores forming. Your provider may recommend treatments, such as:

  • Coating agents. These medicines coat the inside of your mouth. They form a film to protect the sores and minimize the pain you might feel while eating or drinking. Your provider may tell you to swish and spit the medication.
  • Topical painkillers. These gel-like medicines can be put directly on the mouth sores. Your mouth may feel numb when using painkillers. Take care when eating or brushing your teeth because you won't be able to feel if you're hurting your mouth more.

There are other simple steps you can take to lower the pain of mouth sores. You might:

  • Avoid painful foods. Stay away from acidic foods and spicy foods. These could make your mouth feel worse. Don't eat sharp and crunchy foods. These include chips, crackers and pretzels. Instead choose soft foods and cut them in small pieces.

    Alcohol also can hurt an already sore mouth. Don't drink alcohol or use alcohol-based mouthwash. Read the labels carefully.

    Eat foods at room temperature or slightly warm. Hot or cold foods might be painful to eat.

  • Eat small meals more frequently. Cut your food into small pieces and eat slowly.
  • Use a straw. Use a straw for drinking to keep liquids away from the sore parts of your mouth.
  • Continue cleaning your mouth. It may hurt too much to use a toothbrush. Ask your health care team or your dentist about special foam swabs. They may be easier on your gums.

    Rinse out your mouth several times a day. Avoid mouthwashes that contain alcohol.

    Mix water with a little salt to swish around in your mouth. You could also try a combination of baking soda and warm water.

What happens if mouth sores become severe?

If your mouth sores get worse, they can become severe and cause other problems. Sometimes these problems get so bad that you have to stop your cancer treatment for a while.

Complications can include:

  • Infection. Mouth sores offer an easy way for germs to get into your body. Cancer treatment can weaken your immune system and serious infections can happen. Continue cleaning your teeth and mouth during and after treatment to lower your risk of infection.
  • Bleeding. Chemotherapy reduces your body's ability to stop bleeding if it starts. Mild bleeding from your mouth might cause some spotting when you brush your teeth. Sometimes bleeding is severe and can be difficult to stop.

    When your mouth sores bleed, continue cleaning your mouth as best you can. That may mean just rinsing with water.

  • Problems eating and swallowing. Painful mouth sores can make it hard to eat and drink. If you're quickly losing weight, your health care provider may recommend a feeding tube to get you the nutrients you need.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

We use the data you provide to deliver you the content you requested. To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email.

Aug. 30, 2022 See more In-depth

See also

  1. Health foods
  2. Adenocarcinoma: How this type of cancer affects prognosis
  3. Adjuvant therapy for cancer
  4. Alternative cancer treatments: 11 options to consider
  5. Atypical cells: Are they cancer?
  6. Biological therapy for cancer
  7. Biopsy procedures
  8. Blood Basics
  9. Bone marrow transplant
  10. Bone scan
  11. Cancer
  12. Cancer
  13. Cancer blood tests
  14. Myths about cancer causes
  15. Infographic: Cancer Clinical Trials Offer Many Benefits
  16. Cancer diagnosis: 11 tips for coping
  17. Cancer-related fatigue
  18. Cancer pain: Relief is possible
  19. Cancer-prevention strategies
  20. Cancer risk: What the numbers mean
  21. Cancer surgery
  22. Cancer survival rate
  23. Cancer survivors: Care for your body after treatment
  24. Cancer survivors: Late effects of cancer treatment
  25. Cancer survivors: Managing your emotions after cancer treatment
  26. Cancer survivorship program
  27. Cancer treatment
  28. Cancer treatment myths
  29. Cancer-related fatigue
  30. Cancer-related pain
  31. Cancer-related weakness
  32. CAR-T cell therapy
  33. Chemo targets
  34. Chemoembolization
  35. Chemotherapy
  36. Chemotherapy and hair loss: What to expect during treatment
  37. Chemotherapy and sex: Is sexual activity OK during treatment?
  38. Chemotherapy nausea and vomiting: Prevention is best defense
  39. Chemotherapy side effects: A cause of heart disease?
  40. Complete blood count (CBC)
  41. Cough
  42. CT scan
  43. Curcumin: Can it slow cancer growth?
  44. Cancer-related diarrhea
  45. Doppler ultrasound: What is it used for?
  46. Dysphagia
  47. Eating during cancer treatment: Tips to make food tastier
  48. Fatigue
  49. Fertility preservation
  50. Heart cancer: Is there such a thing?
  51. High-dose vitamin C: Can it kill cancer cells?
  52. Honey: An effective cough remedy?
  53. Hyperthermic isolated limb perfusion
  54. Immunotherapy
  55. Infographic: CAR-T Cell Therapy
  56. Intensity-modulated radiation therapy (IMRT)
  57. Intrathecal chemotherapy
  58. Isolated limb infusion
  59. Joint pain
  60. Laryngitis
  61. Low blood counts
  62. Magic mouthwash
  63. Medical marijuana
  64. Microwave ablation for cancer
  65. Mindfulness exercises
  66. Minimally invasive cancer surgery
  67. Monoclonal antibody drugs
  68. Mort Crim and Cancer
  69. MRI
  70. Muscle pain
  71. Needle biopsy
  72. Night sweats
  73. No appetite? How to get nutrition during cancer treatment
  74. Palliative care
  75. PALS (Pets Are Loving Support)
  76. Pelvic exenteration
  77. PET/MRI scan
  78. Precision medicine for cancer
  79. Proton beam therapy
  80. Proton therapy
  81. Radiation therapy
  82. Regional perfusion therapy
  83. Seeing inside the heart with MRI
  84. Self-Image During Cancer
  85. Sentinel lymph node mapping
  86. Shortness of breath
  87. Sisters' Bone Marrow Transplant
  88. Sleep tips
  89. Small cell, large cell cancer: What this means
  90. Stem cells: What they are and what they do
  91. Stereotactic radiosurgery
  92. Surgical biopsy
  93. Targeted drug therapy
  94. Tumor vs. cyst: What's the difference?
  95. Tumor-infiltrating lymphocyte therapy (TIL therapy)
  96. TVEC (Talimogene laherparepvec) injection
  97. Ultrasound
  98. Unexplained weight loss
  99. Stem cell transplant
  100. How cancer spreads
  101. MRI
  102. PICC line placement
  103. When cancer returns: How to cope with cancer recurrence
  104. Wide local skin excision
  105. X-ray