Early-Onset Colorectal Cancer Group

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CORNELIUS A THIELS: I think when it comes to colorectal liver metastases, one of the most important things is trying to get people to surgery, because we do know that surgery is their best chance of a cure. With hepatic artery infusion pump chemotherapy, we're able to offer some of those patients the ability to try to convert them to resectable, meaning convert them to the potential of a curative intent surgery. Hepatic artery infusion pump chemotherapy is where we insert a pump under the skin in the abdomen, and that pump directly connects to the liver. Then, after surgery, patients receive chemotherapy filled into that pump, and then, that chemotherapy slowly goes to the liver over a couple of weeks, and even months after surgery.

And that's important, because we can now treat tumors that are not currently responding to normal chemotherapy, or tumors that are responding, but we need a better response. We need them to shrink more or prevent them from coming back. And so we think this is a very exciting treatment option for very selected patients in order to try to cure them of their colorectal liver metastases.